The human body contains a community of microbial cells and genetic material, called microbiome. There is a growing knowledge that the microbiome plays a vital role in the development and function of important physiological processes as digestion, growth, immune-defense, and brain development. Microbiome is very sensitive to diet, stress, infection, pharmacological intervention.
Intestinal dysbiosis is a sign of several immune disorders as celiac disease or gluten sensitive enteropathy. A genetic predisposition for celiac disease is present in about 30–40% of the general population. But just 2–5% of those persons develop Celiac disease. Among autoimmune disorders, increased prevalence of celiac disease has been found in patients with autoimmune thyroid disease (Graves and Hashimoto’s), type 1 diabetes mellitus, autoimmune liver diseases and inflammatory bowel disease: 1% to 19% in patients with type 1 diabetes mellitus, 2% to 5% in autoimmune thyroid disorders and 3% to 7% in primary biliary cirrhosis in prospective studies. It is important to screen those with autoimmune diseases for celiac disease. Serological tests and identification of the histological changes in proximal small bowel mucosa are useful.
Although gluten is the main environmental trigger, the timing of disease onset following gluten exposure varies greatly between individuals which suggests that other factors play a role.
Disease-associated alterations in microbiome-derived metabolites could not only reflect intestinal dysbiosis but also contribute to dysfunction of the immunoregulatory mechanisms.
Cytokines and pathways contributing to Celiac disease pathogenesis can also be induced by viral and bacterial infections or intestinal pathobionts that could intensify the response to gluten in those who are predisposed.
Treatment of celiac disease with a gluten-free diet:
– reduces the recognized complications and benefits general health and improves life expectancy
– improves glycemic control in patients with type 1 diabetes mellitus
– better absorption of medications for associated hypothyroidism and osteoporosis
New scientific findings open the way to the development of microbiome-informed strategies for personalized preventive and therapeutic measures for immune-mediated disorders such as celiac disease.
Are you ready to balance your microbiome? Join us on the online program ‘Sacred time’
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The focus of the ‘Sacred time’ program is on both environmental and distress factors while working holistically on body, mind and spiritual level. The 12 weeks protocol is presented. How to use the short version of 3 weeks is also elaborated in the program.
Following the program will:
-decrease of the inflammation and toxicity in your mind and body
-get rid of excessive body fluid and fat
-get rid of the brain fog
-figure out your body unique sensitivities
References:
Ch’ng, C. L., Jones, M. K., & Kingham, J. G. C. (2007). Celiac Disease and Autoimmune Thyroid Disease. Clinical Medicine & Research, 5(3), 184-192. doi:10.3121/cmr.2007.738
Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014). The microbiome: stress, health and disease. Mammalian Genome, 25(1-2), 49-74. doi:10.1007/s00335-013-9488-5
Sanz, Y. (2015). Microbiome and Gluten. Annals of Nutrition and Metabolism, 67(Suppl. 2), 28-41. doi:10.1159/000440991
